Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function
نویسندگان
چکیده
منابع مشابه
Dual-specificity MAP kinase phosphatases (MKPs)
Dual-specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase activities in response to both physiological and pathological stimuli. Individual MKPs may exhibit either exquisite specificity towards a single mitogen-activated protein kinase (MAPK) isoform or be able to regulate mul...
متن کاملEmerging Roles of Atypical Dual Specificity Phosphatases in Cancer
The dual specificity phosphatases (DUSPs) are a subfamily within the protein tyrosine phosphatase (PTP) family, with the unique property of being able to hydrolyze phosphoserine or phospho-threonine residues and phospho-tyrosine residues [1]. All DUSPs share the characteristic Class I PTP consensus sequence, D...HC(X)5RS/T, with C representing the essential catalytic cysteine [1]. Unlike other ...
متن کاملFree-energy profiles for catalysis by dual-specificity phosphatases.
PTPs (protein tyrosine phosphatases) are fundamental enzymes for cell signalling and have been linked to the pathogenesis of several diseases, including cancer. Hence, PTPs are potential drug targets and inhibitors have been designed as possible therapeutic agents for Type II diabetes and obesity. However, a complete understanding of the detailed catalytic mechanism in PTPs is still lacking. Fr...
متن کاملPhosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases
Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P) residues of proteins. The DUSPs are linked to the regulation of many cellular functions and signaling pathways. Though many cellular targets of DUSP...
متن کاملDual-specificity phosphatases: critical regulators with diverse cellular targets.
DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. DUSPs have been implicated as major modulators of critical signalling pathways that are dysregulated in various diseases. DUSPs can be divided into six subgroups on the basis of sequence simila...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20184372